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Storage period 50 days after manufacture ; only a minor further increase could be observed. The pH value of the cheese increased from 5.1 to 7.5 - 7.7 during this period. At the end of the declared shelf life 42 days after manufacture ; the added yeast cultures made up to more than 90 % of the living yeast population. No deterioration of the cheeses was observed. It may be concluded that undesired effects in Harzerkse" caused by deleterious yeasts can be avoided by adding those with advantageous properties. Enumeration of Bifidobacteria in Milk Products and Human Faeces a ; Evaluation of AMC-Agar for the Enumeration of Bifidobacteria AMC RCM-agar and different inhibitors ; was developed for selective enumeration of Bifidobacterium longum. AMC agar completely inhibits the growth of Lactococcus lactis, Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus and only allows slight growth of Lactobacillus acidophilus. We report on experiments to examine the general suitability of this medium for the enumeration of bifidobacteria. The growth of 30 strains of the following bifidobacteria-species B. adolescentis, animalis, bifidum, breve, infantis, longum, magnum, angulatum, catenulatum, dentium, gallicum, pseudocatenulatum, pseudolongum, suis, and thermophilus ; on RCM- and AMC-agar was compared. The cell counts of most of these strains were similar on both media with the exception of two B. adolescentis-strains which did not grow on AMC-agar and one B. animalis-strain which was not able to grow on any of the two media. The examination of 12 different milk products gave similar cell counts on both agars. Microscopic examination showed that RCM-agar was less selective and allowed growth of bacteria of other genera. It can be concluded that AMCagar is sufficiently selective for the enumeration of bifidobacteria in milk products see figure on page 34 in German version ; . b ; Bifidobacteria in Human Faeces Bifidobacterium longum BB536 was enumerated in stools of healthy subjects who daily consumed a fermented milk product that contained only that single strain. RCM-agar was chosen as growth medium which contained polymyxin 0.02 g l ; as inhibitor against background flora. Recovery of this strain was found to be better on RCM-based medium than on other growth media also compare to a . Before the study was started, bifidobacteria were 9 10 counted in the magnitude of 10 - 10 per gram faeces sample preparation under aerobic conditions, growth under anaerobic conditions using Anaerocult A system, Merck ; . As expected 3. a number of different colonies of other bacteria were detected. Colonies that were different in their appearance were investigated by light microscopy. In many cases bifidobacteria could easily be identified by their special cell shape but there were also a number of ambiguous cases. 4. Analysis of Plasmid-Encoded Functions in Streptococcus thermophilus The sequence analysis of several plasmids from S. thermophilus revealed the presence of two genes for heat shock proteins sHsp ; and for two restriction modification R M ; systems. To analyze the functions of the gene products plasmid-free derivatives of the corresponding strains were compared with the wildtype strains with regard to temperature-dependence or bacteriophage resistance. Subsequently, the plasmidfree strains and others of the genus Streptococcus and Lactococcus were transformed with plasmid constructs carrying the genes for the sHsp's or the R M systems. The presence of the shsp-genes improved the heat resistance of the transformants and significantly increased the maximal growth temperature. The presence of the genes for R M systems enlarged the 3 5 bacteriophage resistance 10 - 10 fold, depending on the strain, the R M system and the bacteriophage see figure on page 35 in German version ; . 5. Sequence Analysis of Plasmids of Bifidobacterium longum The sequence analysis of plasmids from Bifidobacterium longum was continued by sequencing pAKJ3-2 7.1 kb ; . This plasmid was isolated from a B. longum-strain from the faeces of a breast-feed infant in our laboratory. In the partial sequence obtained so far 6 kb ; a gene for a replication protein RepA ; was identified. The deduced amino-acid sequence of this gene product showed an astonishing high homology of more than 98 % to the RepA protein encoded on plasmid pKJ50. This latter plasmid was also isolated from the faeces of an infant but far away in South Korea. Optimization of Gluconic Acid Production in Whey Permeate by Recombinant Gluconobacter oxidans-Strains The production of gluconic acid by recombinant Gluconobacter oxidans-strains harbouring plasmids which carry the lacZ, Y genes of E. coli in whey permeate was optimized. The influence of some parameters as pH-value, O2-supply and addition of supplements as yeast extract to the substrate was examined. On the basis of these data batch fermentations in a stirred-fermenter were performed. 7.6 g gluconic acid was formed in a 72 fermentation at a constant pH-value of pH 6.0 and the maximal O2supply which was possible with the used fermenter type. The gluconic acid yield may be improved by 6.
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AN EPIFLUORESCENT MICROSCOPIC METHOD WITH MITOCHONDRIAL POTENTIAL SENSOR JC-1 FOR MEASURING DOXORUBICIN-INDUCED CARDIOMYOCYTE DAMAGE AND DEXRAZOXANE ICRF-187 ; CARDIOPROTECTION Kareena L. Schnabl and Brian B. Hasinoff Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2 Doxorubicin is an anticancer drug with a wide range of clinical uses. However, its use continues to be limited by a potentially fatal dose-limiting cardiotoxicity caused partially by its ability to generate reactive oxygen species. Dexrazoxane is a metal ion chelator that has shown great promise in clinical trials as a cardioprotective agent against doxorubicin-induced cardiotoxicity. Because oxidative stress has been demonstrated to disrupt the mitochondrial membrane potential Dym ; , we examined the effect of doxorubicin on the D ym of neonatal rat cardiomyocyte mitochondria in the presence and absence of dexrazoxane ICRF-187 ; . Using epifluorescence microscopy, the mitochondrial Dym was measured with the cationic, fluorescent dye JC-1, which is readily taken up and forms red fluorescing "J-aggregates" in mitochondria with an intact Dym. Damaged cardiomyocytes with a compromised Dym fluoresce green. In our study, the average red green pixel intensity ratio decreased significantly P 0.001 ; with increasing pharmacological concentrations of doxorubicin. At low sub-micromolar concentrations of doxorubicin, dexrazoxane protected against doxorubicin-induced mitochondrial damage. Thus, doxorubicin cardiotoxicity is associated with oxidative mitochondrial damage and dexrazoxane protects at the level of the mitochondria possibly through the ability of its hydrolysis product ADR-925 ; to prevent iron-based oxygen free radical damage. Support: CIHR, MHRC Abstract was presented in New Orleans at the American Association of Cancer Research Conference in March.
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Eleventh Circuit: Joiner v. General Electric Co., 78 F.3d 524 11th Cir. 1996 ; admitting expert evidence on causation of lung cancer through exposure to polychlorinated biphenyls because evidence was reliable and relevant under Daubert; Daubert standards intended for conflicting expert views to be admitted, not excluded, as long as they are scientifically legitimate ; . District of Columbia Circuit: Ambrosini v. Upjohn Co., 101 F.3d 129 D.C. Cir. 1996 ; ruling that teratologist's testimony that drug caused birth defects is reliable under Daubert even though he failed to explain his scientific methodology; expert ruled out other possible causes for defects based on family history and had significant experience in the field ; . State Courts: Florida: Berry v. CSX Transportation Inc., 709 So.2d 552 Fla. Dist. Ct. App. 1998 ; overturning rejection of expert testimony as going beyond the "general acceptance" inquiry of Frye test where expert's diagnosis was based on a scientifically acceptable method and his opinion was based upon sufficient epidemiological data, facts and personal observation ; . Pennsylvania: Adams v. Lord Corp., 97 CCH Prod. Liab. Rep. 15, 121 Pa. Comm. Pleas 1998 ; refusing to grant defense summary judgment and ruling plaintiff's experts could testify even if their theory was controversial because they were based on generally accepted principles from their fields of expertise ; . 11.5 See: New Hampshire: Baker Valley Lumber v. Ingersoll-Rand Co., 813 A.2d 409 N.H. 2002 ; . Texas: E.I. Dupont de Nemours & Co. v. Robinson, 923 S.W.2d 549 Tex. 1995 ; . 11.6 Alabama: Slay v. Keller Industries, Inc., No. 1001091, 2001 Ala. LEXIS 439 declining to adopt Daubert standard and conducting analysis of admissibility of testimony regarding aluminum ladder under Frye test ; . Washington: Washington v. Copeland, 130 Wash.3d 244, 922 P.2d 1304 1996 ; approving admission of DNA and statistical evidence under the Frye standard and rejecting use of the Daubert standard under Washington rules of evidence ; . 11.7 General Electric Co. v. Joiner, 522 U.S. 136, 118 S.Ct. 512, 139 L.Ed.2d 508 1997 ; On certiorari to determine what standard a federal appellate court should apply in reviewing a federal trial court's decision to admit or exclude expert testimony, Court held that abuse of discretion is the appropriate standard and found the district court in instant action did not abuse its discretion by excluding certain proffered expert testimony that indicated a link between exposure to polychlorinated biphenyls and small cell lung cancer. ; . See also: Sixth Circuit: Hardyman v. Norfolk Southern Railway Co., 243 F.3d 255 6th Cir. 2001 ; abuse of discretion for district court to exclude expert testimony on causation, based on differential diagnosis, on grounds that it was conclusory and unsupported by an objective, reliable methodology; differential diagnosis is an accepted method of determining causation ; . Seventh Circuit: Burns Philp Food, Inc. v. Cavalea Continental Freight Inc., 135 F.3d 526 7th Cir. 1998 ; applying abuse of discretion standard to uphold Daubert exclusion of scientific expert testimony elicited to support an environmental contamination claim and depakote, for example, cozaar drug class.
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The floor of the third ventricle, and the hypothalamus. It also affects other extraaxial areas, such as the interhemispheric fissure and cerebral cortex. Cranial neuropathy is the most common neurologic sign. The facial nerve, optic nerve, and eighth nerve are frequently involved 1, 8 ; . Hydrocephalus can be caused by periventricular inflammation around the aqueduct, fourth ventricle, foramina of Luschka and Magendie, or inflammation and or fibrosis of the subarachnoid space 6 ; . Secondary extension through Virchow-Robin spaces has been reported with nodular and linear enhancement extending from the cortex to the deep white matter 9 ; . Parenchymal sarcoidosis is less common than meningeal sarcoidosis. Most often, it appears as homogeneously enhancing isolated or multiple nodules, or as ringlike enhancement. It can occur in any part of the brain 6, 7, 10 ; . Recently, periventricular and subcortical white matter abnormalities have been reported in sarcoidosis. They appear as areas of low density on CT scans, as areas of low intensity on T1-weighted MR images, and as areas of high intensity on T2-weighted MR images. No enhancement is seen. These changes may represent ischemia associated with vasculitis or infiltration of subependymal sarcoid granulation tissue 11, 12 ; . Our patient had a large cystic mass in the pituitary with thick and enhanced walls involving the infundibulum and the hypothalamus. The differential diagnosis of a cystic pituitary mass such as this includes a cystic adenoma, a Rathke's cleft cyst, and a craniopharyngioma. Involvement of the infundibulum and hypothalamus is important in establishing a diagnosis, since this is not usually seen in these conditions. In addition, the wall of a Rathke's cleft cyst is usually thin, smooth, and does not enhance, which are findings different from those in our patient. This patient had both anterior and posterior pituitary insufficiency, which is rare, as benign neoplasms, such as adenoma, craniopharyngioma, or Rathke's cleft cyst, do not usually cause panhypopituitarism and diabetes insipidus. On the other hand, pituitary insufficiency is frequently noted in inflammatory diseases, such as sarcoidosis, tuberculosis, lymphocytic hypophysitis, malignant neoplasms, and metastasis 13 ; . In our patient, who had abnormalities of the pituitary, infundibulum, and hypothala and diazepam.
| Figure 1 The mechanism of drug release from a TimeDelayed Capsule. is often treated with high-dose anti-inflammatory agents, which have a real potential for serious irreversible adverse effects. Localised treatment would reduce the dosage level and subsequent side-effects. Additionally, preferential absorption of drugs has also been demonstrated for different sites of the GI tract. For example, leuprolide shows absorption variability throughout the GI tract in rats, with maximum absorption available in the colon Zheng et al., 1999.
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Gender. While blood pressure was reduced in all racial subgroups examined, too few non-White patients were enrolled to compare the dose-response of losartan in the non-White subgroup. Reduction in the Risk of Stroke: The Losartan Intervention For Endpoint reduction in hypertension LIFE ; study was a multinational, double-blind study comparing COZAAR and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy. Patients with myocardial infarction or stroke within six months prior to randomization were excluded. Patients were randomized to receive once daily COZAAR 50 mg or atenolol 50 mg. If goal blood pressure 140 90 mmHg ; was not reached, hydrochlorothiazide 12.5 mg ; was added first and, if needed, the dose of COZAAR or atenolol was then increased to 100 mg once daily. If necessary, other antihypertensive treatments e.g., increase in dose of hydrochlorothiazide therapy to 25 mg or addition of other diuretic therapy, calcium-channel blockers, alpha-blockers, or centrally acting agents, but not ACE inhibitors, angiotensin II antagonists, or beta-blockers ; were added to the treatment regimen to reach the goal blood pressure. Of the randomized patients, 4963 54% ; were female and 533 6% ; were Black. The mean age was 67 with 5704 62% ; age 65. At baseline, 1195 13% ; had diabetes, 1326 14% ; had isolated systolic hypertension, 1469 16% ; had coronary heart disease, and 728 8% ; had cerebrovascular disease. Baseline mean blood pressure was 174 98 mmHg in both treatment groups. The mean length of follow-up was 4.8 years. At the end of study or at the last visit before a primary endpoint, 77% of the group treated with COZAAR and 73% of the group treated with atenolol were still taking study medication. Of the patients still taking study medication, the mean doses of COZAAR and atenolol were both about 80 mg day, and 15% were taking atenolol or losartan as monotherapy, while 77% were also receiving hydrochlorothiazide at a mean dose of 20 mg day in each group ; . Blood pressure reduction measured at trough was similar for both treatment groups but blood pressure was not measured at any other time of the day. At the end of study or at the last visit before a primary endpoint, the mean blood pressures were 144.1 81.3 mmHg for the group treated with COZAAR and 145.4 80.9 mmHg for the group treated with atenolol [the difference in systolic blood pressure SBP ; of 1.3 mmHg was significant p 0.001 ; , while the difference of 0.4 mmHg in diastolic blood pressure DBP ; was not significant p 0.098 ; ]. The primary endpoint was the first occurrence of cardiovascular death, nonfatal stroke, or nonfatal myocardial infarction. Patients with non-fatal events remained in the trial, so that there was also an examination of the first event of each type even if it was not the first event e.g., a stroke following an initial myocardial infarction would be counted in the analysis of stroke ; . Treatment with COZAAR resulted in a 13% reduction p 0.021 ; in risk of the primary endpoint compared to the atenolol group see Figure 1 and Table 2 this difference was primarily the result of an effect on fatal and nonfatal stroke. Treatment with COZAAR reduced the risk of stroke by 25% relative to atenolol p 0.001 ; see Figure 2 and Table 2.
A clinical effectiveness pharmacist at a primary care trust complained that materials issued by Merck Sharp & Dohme misrepresented the British Hypertension Society's BHS ; recommendations for combining antihypertensives. The items at issue, an A4 card, an A3 poster and a mouse mat, featured a treatment `flow chart' which appeared to be identical to that published by the BHS in its guidelines for the management of hypertension. A box of text in the published guidelines explained that `A' in the AB CD algorithm stood for `ACE Inhibitor or angiotensin receptor blocker [AIIA]'. In the guidelines distributed by Merck Sharp & Dohme the order of the two classes of medicines had been reversed such that it was stated that `A' represented `Angiotensin II Antagonist or ACE Inhibitor'. The complaint alleged that the material thus highlighted AIIAs in preference to ACE inhibitors and distorted the BHS guidelines to such an extent that they no longer reflected those originally published. With regard to the A4 card the complainant noted that it had a prominent BHS logo in the body of the material and a small Merck Sharp & Dohme logo at the bottom. Many GPs had this poster on their surgery wall but might miss the subtle, but important change of the word ordering. The Panel noted that the presentation of the BHS recommendations on the poster mimicked the style of the original published AB CD algorithm. The text explaining what `A' stood for had, however, been changed such that the order of `ACE inhibitor or angiotensin receptor blocker' had been reversed. The Panel noted that the published guidelines contained a section headed `Recommendations for drug selection in practice The BHS AB CD algorithm' which explained that the AB CD protocol was not restrictive and provided a template that allowed the use of all classes of antihypertensive medicine. All things being equal and when there was no compelling indication for treatment with a specific class of medicine, then the cheapest should be used. This explanation was not included in the guidelines distributed by Merck Sharp & Dohme. The Panel considered that the layout of the A4 card was such that readers would assume they were reading the BHS guidelines as published and this was not so. Given that AIIAs were mentioned before ACE inhibitors readers might assume that AIIAs were the first choice of medicine to be used for blocking the rennin-angiotensin system. The Panel noted that the additional information that where a choice existed then the cheapest medicine should be chosen was not included on the A4 card. The Panel considered that, on balance, the card was misleading as alleged. A breach of the Code was ruled. The A3 poster, in addition to showing the company's version of the BHS recommendations for treating blood pressure featured the Cozwar product logo and the following claims: `Where should COZAAR be considered? In line with the BHS ABCD algorithm, COZAAR could be used rather than a.
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1. Roberts KH, Yu K, Van Stralen D. Patient safety as an organizational systems issue: Lessons from a variety of industries. In Youngberg BJ, Hatlie MJ, eds. The patient safety handbook. Sudbury MA ; : Jones & Bartlett; 2004: 169-86. 2. Sorra JS, Nieva VF. Hospital survey on patient safety culture [online]. AHRQ Publication No. 04-0041, Sep 2004. Agency for Healthcare Research and Quality, Rockville MD ; . Available from Internet: : ahrq.gov qual hospculture, because cozaar side affects.
1. Schein, OD, Hibberd PL, Starck T, Baker AS, Kenyon KR. Microbial contamination of in-use ocular medications. Arch Ophthalmol 1992; 110: 82-85. Spickett C. Studies of Cellular Responses to Purite and Other Preservatives. Strathclyde, UK: University of Strathclyde; 2001. Kreiner C. Biochemical aspects of ophthalmic preservatives. Contacto 1979; Nov: 10-14. Gasset AR, Ishii Y, Kaufman, HE, Miller, T. Cytotoxicity of ophthalmic preservatives. J Ophthalmol 1974; 78: 98-105. Grant, WM, Schuman JS. Toxicology of the Eye. Springfield, IL: CC Thomas; 1990. De Saint Jean M, Brignole F, Bringuier A, Bauchet A, Feldmann G, et al. Effects of benzalkonium chloride on growth and survival of chang conjunctival cells. Invest Ophthalmol Vis Sci 1999; 40: 619-630. De Saint Jean M, Debbasch C, Brignole F, Rat P, Warnet JM et al. Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells. Curr Eye Res 2000; 20: 85-94. Burnstein, NL, Klyce SD. Electrophysiologic and morphologic effects of ophthalmic preparations on rabbit cornea epithelium. Invest Ophthalmol Vis Sci 1977; 16: 899-911. de Jong C, Stolwijk T, Kuppens E, de Keizer R, van Best J. Topical timolol with and without benzalkonium chloride: epithelial permeability and autofluorescence of the cornea in glaucoma. Graefes Arch Clin Exp Ophthalmol 1994; 232 4 ; : 221-224. Gobbels M, Spitznas M. Corneal epithelial permeability of dry eyes before and after treatment with artificial tears. Ophthalmology 1992; 99 6 ; : 873-878. Morgan JF. Problems associated with current care systems for contact lenses. Practical Optometry 1990; 1 ; : 8. Way WA, Matsumoto S, Apel LJ, Wiese A, Vehige TJ et al. Purite as a non-disruptive preservative for lubricating eye drop solutions in comparison to alternative preservatives. Invest Ophthalmol Vis Sci 2001; 4: S223-B196. Block SS. Disinfection, Sterilization, and Preservation. Malvern, PA: Lea & Febiger; 1991. Masschelein WJ, Rice RG. Chlorine Dioxide. Chemistry and Environmental Impact of Oxychlorine Compounds. Ann Arbor, Mich: Ann Arbor Science Publishers; 1979. Purite. 1-3 Bio-Cide International Inc, Norman, OK, 1998. Vaughan JS, Porter DA. A new in vitro method for assessing the potential toxicity of soft contact lens care solutions. CLAO J 1993; 19: 54-57 and cyclobenzaprine.
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I sorry that there are so many "ifs" "ands", and "buts" in the following "Basic Program" and book. You can be certain about Death and Taxes, but even I not entirely certain about everything in this book. Reading it, however, may help to deepen your understanding of your own hormonal nature, so that you feel more confident while trying out some of what I have suggested. My publisher, my companies, my family, and I cannot possibly tell you everything you may need to know to be well advised about optimally supporting your health and happiness. Furthermore we will assume no liability for any bad result you might get from following any of my suggestions anywhere in this book, or otherwise expressed by me publicly or privately. By giving you my opinions, I just exercising my right to free speech. Whatever you read, whatever you hear, and whatever you decide to do, you will be reading, hearing and doing it at your own risk. If you are in doubt about anything I have said, I suggest that you double-check it against the best available research. Very likely you will discover many things that I have never even considered. I certain that I have made many errors in this book. Even your doctor may not know enough to advise you well, but with all of the special legal protections the medical profession has bought and won for itself, he is at least in a safer legal position to risk personally prescribing bad advice. I recommend that most everyone avoid most polyunsaturated fats, fried foods and supplemental Iron. I also recommend eating just enough purified fish oil to get an average of about 300mg of EPA and 200 mg of DHA per day, cutting back on your dietary carbohydrates, increasing the proportion of your calories coming from "oleic acid, " saturated fats and protein, slowly building up to about 6-12 mg of Iodide per day 40-80 times the USDA "Daily Value" ; , adding back more acid producing bacteria to your diet, and women switching from any of the commonly medically prescribed, metabolism-slowing, "birth control" means they may be using, to the less hormonally upsetting and less diseases causing contraceptive alternatives discussed here in. You may not yet need any of the other advice and or hormonal supplements discussed in this Basic Program section. If you do need any of the other supplements discussed here, or in the later chapters of this book, then do not expect that finding the exact balance you need will be quick, easy, or entirely safe. As under-tested and unrefined as it is, however, I have found my approach to hormonal rejuvenation is a lot better than allowing myself to continue following common medical miss-advice, and prematurely becoming grumpy, falling-apart, suffering and dying. It is great to feel young and in love again.
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Increasing quality of products and improving availability of certain foods. A number of the MRLs are harmonized with MRLs for veterinary drugs already established by Canada's major trading partners such as the United States. In addition, the amendments include MRLs that are harmonized with levels established by the Codex Alimentarius Commission and adopted by many countries. There will not be an increased cost to government from the administration of these amendments to the Regulations. Compliance costs will not be a factor as the use of these drugs at the production level is optional. Consultation Prior to pre-publication in the Canada Gazette, Part I, consultation was undertaken with provincial and federal health and agriculture authorities, Canadian veterinary colleges, provincial veterinary medical associations, the Canadian Veterinary Medical Association, the Dairy Farmers of Canada, the Aquaculture Association of Canada, the Canadian Feed Industry, the Canadian Chicken Marketing Agency, the Canadian Turkey Marketing Agency, the National Dairy Council of Canada, the Further Poultry Processors Association of Canada, the Canadian Cattlemen's Association, the Canadian Animal Health Institute, the Canadian Meat Council, the Fisheries Council of Canada, the Canadian Pork Council, the Canadian Poultry and Egg Processors Council, the Federal Provincial Territorial Committee on Food Safety Policy, the Canadian Beef Export Federation, the Canadian Food Inspection Agency, Agriculture and Agri-Food Canada, and the Department of Fisheries and Oceans.
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We covered lots of information in this powerful newsletter. I proud to be a chiropractor and equally proud of you, my family of wonderful patients and friends. You should be proud of yourselves for being at the leading edge in healthcare and for choosing the "Chiropractic Lifestyle" for your family. Life is wonderful and we all live a blessed life. It is a privilege and honor to serve my patients and to team up with you and help you to accomplish all of your health goals. Please share this wealth of valuable information with those you care for. The best gift you can give anyone is a gift of HOPE. As we kick off 2006, I wish for you a magical year, a year of abundance, joy, vitality, and of maintaining the highest standards for your health and your family's health. I wish for you a "Dream-come-true New Year." This is the time of year to be most grateful for all of the miracles in our lives. What a perfect opportunity to share precious moments with family and friends. There has never been a better time to share your love with all of those around you. Together, we can all help to make our world a better and healthier place to live. Are you ready to make 2006 the healthiest, happiest and most prosperous year EVER? GO FOR IT! You deserve it.
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