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Shakiba Elaheh1, Yaghobi Ramin2, Ramzi Mani3. 1- Dept. of Microbiology, Islamic Azad University, Jahrom, 2- Transplant Organ Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, 3- Hematology and Oncology Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Background: Hemorrhagic cystitis HC ; is an important cause of morbidity and mortality in bone marrow transplant BMT ; recipients, with an incidence varying from 7-70% in BMT patients. HC presentations are classified as early and late onset and one of the causative agents of late onset HC is viral infections like BK polyomavirus BKV ; , cytomegalovirus CMV ; and adenovirus ADV ; . Objectives: The primary objective of this research was to determine the prevalence of BKV, ADV and CMV infections in BMT recipients suffering from late onset HC. The role of other risk factors, including immunosuppressive and anti-GVHD drugs, hematological and biochemical characteristics, clinical conditions, grade of GVHD in HC presentations were also investigated. Materials and methods: We studied 30 BMT recipients and 24 BMT donors, with at total of 293 EDTA-treated blood samples and 293 urine samples collected. The first samples were collected pre-transplantation from BMT recipients and donors and post-transplantation samples were collected one per week for 100 days from BMT recipients only. Incidence and grade of HC was determined in BMT recipients. In-house BKV-monoplex PCR and inhouse ADV CMVmultiplex PCR assays were performed to determine the prevalence of these viruses with HC incidence in the BMT patients. All data were statistically analyzed with SPSS version 12. Results: Among BMT recipients, the median incidence of HC was 53.3% and 36.7% had sonographic record of blood clots in the bladder. Significant correlations were found between BKV-PCR and ADV-PCR positive results with HC presentation. Hematological and biochemical characteristics correlated significantly with BKV-PCR, ADV-PCR and CMV-PCR positive results and HC presentation. A significant correlation was found between the use of prophylactic dose but not therapeutic dose of anti-GVHD drugs with HC presentations in BMT recipients. Conclusion: The significant correlations between HC clinical presentations and the presence of BKV and ADV, and results of hematologic and biochemical tests, indicates that monitoring these viral and biological indexes have a critical role in the management of preventive and.
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76. ARABMED Annual REPORT, The Arab Medical Journal Dr. Hassan Naggar, Germany President of the Arab Medical Union in Europe 77. Arab Medical Union in Europe & the Cooperation with Ajman University of Science an Technology Dr. Faidi Omar Mahmoud Germany Chair of Scientific Committee, the Arab Medical Union in Europe 78. The role of Arabmed in europa in development and implementation of strategic plan of Arab Academy of Medical Scince Dr. Amer A Hosin Chair, Policy Planning Development, and ARABMED NGOs Affairs Committee 79. Annual report and presentation of the Innovative Medical Environment Committee of Ajman University Delegation of Innovative Medical Environment Committee, Ajman University, UAE 80. National framework for introducing and maintaining Evidence Based Practice in The Middle East Dr. Mousa Al-Kurdi President, British Arab Medical Association in UK.
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RAN Speed Measures The student named the single-dimension colors range 23.4-38.0 sec. ; , forms range 22.028.0 sec. ; , and numbers range 18.6-28.0 sec. ; at close to normal limits before and after medication. In contrast, the pre-medication naming times for color-form 103.5 sec. ; and color-number combinations 101.8 sec. ; were more than two standard deviations above the control-group means of 43.6 and 38.5 sec., respectively. RAN Slowness-Factor Ratio A calculated "slowness" ratio indicated that color-form speed was reduced by a factor of 1.96 and color-number speed by 1.92. Post-medication RAN measures indicated that naming times decreased for color-form 58.0 sec. ; and color-number 52.0 sec. ; combinations and remained close to normal. The slowness ratios for naming both colorform 1.21 ; and color-number 1.04 ; combinations were within a normal range. The results are shown below. Cognitive Measures The pre- and post-medication cognitive-ability measures WJ-R ; indicated significant improvements in Auditory Processing Sound Blending; Sound Patterns ; and Long-Term Memory - especially for Memory for Names. Processing Speed Visual Matching; Cross Out ; was consistentlybelow normal for all administrations and did not change significantly with medication. The results are shown below.
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Abbreviations: ACE: angiotensin-converting enzyme; ARB, angiotensin receptor blocker; -blocker: -blocker approved for heart failure; CI, confidence interval; OR, odds ratio. * All reference groups for concurrent therapies are those individuals not receiving the specific drug. Including the Veterans Health Administration, Tricare, and Indian Health Services.
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