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We are grateful to Professor R. C. Thomas and Dr. Frank Kirchhoff for helpful comments. A. Verkhratsky and H. Kettenmann's research is supported by grants from SonderForschungsBereich 1534. R. K. Orkand is supported by National Science Foundation EPSCoR ; and the National Institutes of Health National Institute of Neurological Disorders and Stroke, Minority Institutional Research Development Program, and Fogarty Foundation, for instance, flonase asthma.
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Rouhi et al.: Effects of Ginger on the Improvement of Asthma treatment get improved to 5.04 times per week P 0.05 ; . The mean chest tightness per week in the test group before treatment was 3.41 times a week which after treatment it improved to 2.41 times a week P 0.05 ; .Results of the group taking placebo : The frequency of dyspnea before and after treatment in the control group was the same p N.S. ; . The frequency of chest tightness in the control group shown to be as follow : 37 persons 80.4% ; before treatments had chest tightness, in 3 persons 6.5% ; after treatment the sense of chest tightness disappeared, while in 4 persons 8.7% ; chest tightness accounted after taking placebo. Finally the chest tightness before and after treatment did not show significant difference p N.S. ; . In the control group 33 persons 71.7% ; were in stage 4 before and after treatment. 1 person 2.2% ; improved from stage 4 to stage 3 after treatment, and 1 person 2.2% ; changed from stage 3 to stage 4 after treatment. These changes were not significant statistically p N.S. ; . The mean nocturnal coughing in the control group before treatment was 3.47 times per week, while after taking placebo reached 3.21 times per week P 0.05 ; group before treatment was 6.23 times per week reached after treatment reached 5.82 times per week p N.S. ; . The mean dyspnea attacks in the control group before treatment was 4.1 times per week which after treatment reached 3.34 times per week P 0.05 ; . who and ginger which is significant. Concerning the mean FEF25-75, FEV1 and FVC between the test and the control groups, them was no significant difference. it may be that to determine the spirometry findings before and after using ginger amount is need and 2 months was not enough. There are only few data on the actions of ginger. Gingerols, in particular 6 - gingerol, have been identified as the active ingredient of ginger, and are also responsible for its characteristic taste. There are several mechanisms which could explain the possible antiemetic effects of ginger. In an animal model, for instance, it was demonstrated that 6- gingerol enhanced gastrointestinal transport Yamahara et al., 1990 ; This and other compounds of ginger have also been shown to have anti- hydroxytryptamine activity in isolated guineapigileum Yamahara et al., 1989; Huang et al., 1991 ; Galanolactone, another constituent of ginger, is a competitive antagonist at ileal 5-HT3 receptors Phillips et al., 1993 ; . Thus antiemesis could be brought out by effects on the gastric system through 5-HT3 antagonism. This hypothesis is weakened by the results of a randomized, placebo-controlled, crossover study in human volunteers reporting that oral ingestion of powdered ginger root did not affect gastric emptying rate Holtmann et al., 1989 ; . In contrast, effects on the central nervous system may be involved. This notion is strengthened by the finding that, in an animal model, oral 6-gingerol prevented vomiting in response to cyclophosphamide. A central effect is also implicated by studies reporting that ginger partly prevents motion sickness symptoms in healthy human volunteers. Another study investigating motion sickness, however, reported no effects of ginger on the vestibular and oculomotor system. With a herb commonly used as a foodstuff and spice, one is inclined to assume that it is free of serious adverse effects. However, this can be a dangerous fallacy. For instance in doses taken with food, a spice may be safe, yet when taken in higher doses as a drug, this might not apply. There were no reports of adverse reactions to ginger compared with placebo in any of the above studies. The British Herbal compendium documents no adverse effects of ginger Bradley, 1990 ; . The identification of medicinal herbs such as garlic, ginger and nutmeg provides an opportunity to investigate west Indian plants used to treat asthma to determine whether they possess pharmacological properties. scientific investigations have shown that some of these herbs possess pharmacological and anti inflammatory properties, and these may be useful in suppressing the characteristic exaggerated immune response in asthma Ernst et al., 1998; Garcia et al., 1999; Yuri et al., 2005 ; . Therefore since using Ginger has no important side effects, we commend that it is used as a standard 375.
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