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Gastric lymphoma, Blood. 2003, 102: 1931-1932. Publication No. : 78796 ; Cheng C., Chan O.O., Hui W.M. and Lam S.K., Coping Strategies, Illness Perception, Anxiety and Depression of Patients with Idiopathic Constipation: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18 3 ; : 319-26. Publication No. : 80540 ; Cheng V.C., Lo C.M. and Lau G., Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far East, Seminars in Liver Disease. 2003, 23 3 ; : 239-250. Publication No. : 87760 ; Cheung B.M.Y., Wong L.Y.F., Li Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Neuropeptides. 2004, 38: 126. Publication No. : 95725 ; Cheung B.M.Y., Lau C.P. and Kumana C.R., Combination therapy for hypertension, Hong Kong Medical Journal. 2003, 9: 224-6. Publication No. : 95889 ; Cheung B.M.Y. and Kumana C.R., Effectiveness of lipid lowering drugs in general practice: study had two major flaws, British Medical Journal. London, BMJ Publishing Group, 2003, 347 7405 ; : 51. Publication No. : 86278 ; Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181 2 ; : 339-345. Publication No. : 86262 ; Cheung B.M.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes, British Journal of Clinical Pharmacology. Blackwell Publishing, 2004, 57 5 ; : 640-651. Publication No. : 86265 ; Cheung B.M.Y. and Lau C.P., New opportunities and challenges in heart protection, Journal of Hong Kong College of Cardiology. 2003, 11: 1-3. Publication No. : 95896 ; Cheung R.T.F. and Hachinski V., Cardiac effects of stroke, Current Treatment Options in Cardiovascular Medicine. 2004, 6: 199-207. Publication No. : 87533 ; Cheung R.T.F., Eliasziw M., Meldrum H.E., Fox A.J. and Barnett H.J., Risk, types, and severity of intracranial hemorrhage in patients with symptomatic carotid artery stenosis, Stroke. 2003, 34: 1847-1851. Publication No. : 87545 ; Cheung R.T.F. and Fung P.C.W., Role of free radicals in developing drugs for stroke, Drug Medi-Bank: Hong Kong. 2004, 1: 4-7. Publication No. : 87535 ; Cheung R.T.F., Stroke prevention in clinical practice for primary care physicians, Hong Kong Practitioner. 2004, 26: 81-92. Publication No. : 87536 ; Cheung R.T.F. and Zou L., Use of the original, modified, or new intracerebral hemorrhage score to predict mortality and morbidity after intracerebral hemorrhage, Stroke. 2003, 1717-1722. Publication No. : 87546 ; Cheung Y.B., Khoo K.S., Wong Z.W., See H.T., Toh H.C., Epstein R., Ng G.Y. and Tan S.B., Quick-FLIC: a short questionnaire for assessing quality of life of cancer patients., Acta Oncologica. 2003, 42 1 ; : 36-42. Publication No. : 86256 ; Chim J.C.S., Wong A.S.Y. and Liang R.H.S., Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance, British Journal of Haematology. 2003, 122 4 ; : 571-578.
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Fig. 3. Effect of Eqn on the level and half-life of apoA-I mRNA. Cells were cultured without or with Eqn 10 M ; for 24 h in MEM minus phenol red and supplemented with 10% CTFBS. Cells were then cultured for additional periods ranging from 0 to 24 the presence of actinomycin D 1 g Total RNA was isolated at the indicated time points and then was separated by 1.5% agarose gel electrophoresis. ApoA-I mRNA was determined by Northern analysis top ; . The relative intensities of the hybridized apoA-I mRNA signal and ethidium bromide-stained 28S rRNA were quantitated by PhosphorImager analyses. All results were normalized with ethidium bromide-stained 28S rRNA to correct for loading variations. The normalized apoA-I mRNA levels, in arbitrary units, are presented on a log scale. The half-lives for the apoA-I mRNAs were obtained from the first-order decay calculation. Solid circles and solid squares represent RNA samples isolated from cells treated without and with Eqn, respectively. Results represent means SEM of four experiments. An unpaired t-test was used to compare the half-life of the Eqn-treated group with that of the drug-vehicletreated group.
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A final extension at 72C for 10 minutes. Samples for the detection of T. vaginalis were initially heated at 94C for 5 minutes, followed by 35 cycles of denaturation at 94C for 1 minute, annealing at 47C for 1 minute, and extension at 67C for 1 minute with a final extension at 67C for 10 minutes. Amplified products were resolved by electrophoresis on 2% agarose gels, stained using ethidium bromide, and then visualized. A positive sample and a negative control were always used. Occasionally, because we had primers available, we performed a nested PCR for the detection of C. trachomatis using primers FLS FLA and N2 N4 as previously described28 to assess consistency. Data Management and Analysis Data were double-entered using FoxPro 2.6 Microsoft Corp. ; . These data were then converted to Stata 7.0 Stata Corp. ; using Stat Transfer version 5. Associations between concurrent STIs as well as between STIs and other demographic and behavioral characteristics were analyzed using contingency tables for categorical variables and analysis of variance for numerical variables. Multivariate logistic regression analysis was performed with backward elimination. P values were calculated using the Pearson chi-squared test. Results Sociodemography A total of 211 FSWs between the ages of 16 and 59 mean age, 27 years ; were recruited. Local EHP women comprised 71% of the total and 19% were originally from the neighboring Simbu Province, which shares the western border with EHP. Between 1% and 2% of the women came from other provinces served by the same highway, in particular Western Highlands and Enga further west of EHP and Madang and Morobe on the east coast. Similar number of women also came from other provinces not linked by the highway, which included East Sepik, MilneBay, East New Britain, and the National Capital District. Most of the women were either living in settlements 45% ; or rural hamlets 39% ; . The remaining 16% were residents of the 2 towns, Goroka and Kainantu. More than half 54% ; of the women interviewed at the time of the study were divorced, 8% were separated with their husbands living away from home for studies or work, 5% were widows, 15% were married, and 19% claimed they had never married. Forty-eight percent of the women reported having no children. The number of children ranged between 1 and 5 among FSWs who had children, with more 21% ; of them reporting having only 1 child. Almost two third 66% ; of the women had a primary school education of whom 23% reported having completed grade 6. Only 6% of the FSWs completed secondary education and had been to college or a tertiary institution. Twenty-eight percent of them had never been to school. Prevalence of Sexually Transmitted Infections Prevalence of the respective STI was determined in all participating FSWs, except in 35 women for whom results of syphilis were not available. Eleven of the latter women 11 of 35 ; were negative for the other STIs, hence of the 200 FSWs that were analyzed, 74% were positive for at least 1 of the 4 pathogens that were detected. As summarized in Table 1, T. vaginalis predominated at 51% 108 of 211 ; . Prevalence rates of N. gonorrhoeae, C. trachomatis, and T. pallidum were 21% 44 of 211 ; , 19% 41 of 211 ; , and 24% 42 of 176 ; , respectively. None of the FSWs was positive for HIV, although samples from 7 women that appeared.
Correspondence: Dr. Mariam Faruqui Department of Obstetrics and Gynaecology, Dhaka Medical College Hospital, Dhaka, Bangladesh.
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GAAP procedures and, in so doing, misled present and potential investors by artificially inflating Daou's revenues above what should have been reported. [12] Similarly, we hold that plaintiffs' claims regarding employee training and turnover contain sufficient particularity to support a securities fraud claim. Plaintiffs allege that various defendants made statements indicating that Daou instituted a training program called "Daou University, " at which Daou employees were taught technical skills and became certified in computer networking languages and programs. Moreover, plaintiffs contend, in May 1998, D. Daou and McGee represented that Daou had an ongoing program with local universities in San Diego whereby Daou brought in college students to Daou University to train them in systems and networking. According to plaintiffs, neither Daou University, nor the company's program with local college students, existed. Plaintiffs further assert that defendants misled potential investors by understating employee turnover and attrition. The district court concluded that these allegations lacked sufficient particularity to be actionable. As to employee attrition, for example, the district court noted: The one allegation of any substance, Plaintiffs' contention that employee attrition was actually 40%, not 6.8% as represented by Defendants, does not establish misrepresentation on Defendants' part. Defendants' statements that attrition among technical employees was at 6.8% was made in July 1998, and confidential witnesses' statements that the attrition rate for all employees was at 40% was made in the first quarter of 1998. However, the complaint itself qualifies the allegation of employee turnover by stating that "[e]mployee turnover, especially among Field Service engineers, exceeded 40%, " whereas defendants stated that "attrition within the technical.
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Doi 10.1136 bmj.38568.639688.F7 Institute of Clinical Pharmacology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany Uwe Trger consultant in clinical pharmacology Stefanie M Bode-Bger professor in clinical pharmacology Department of Neurology, Otto-von-Guericke-University Hartmut Lins senior registrar in neurology Claus-Werner Wallesch professor in neurology INSERM U705, CNRS UMR 7157, University Paris 7, University Paris 5, Hopital F Widal, 200 rue du Faubourg saint-Denis, F-75475 Paris, cedex 10, France Jean-Michel Scherrmann professor in pharmacy Correspondence to: U Trger uwe.troeger medizin -magdeburg.
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