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Brian J. Gestring, MS * , Pace University, 1 Pace Plaza, Room Y23, New York, NY 10038-1502; Carl M. Selavka, PhD * , Massachusetts State Police, 59 Horse Pond Road, Sudbury, MA 01776; Jeff Schweitzer, PhD, University of Connecticut, East Main Street, Waterbury, CT 06702; Jacob I. Trombka, PhD, NASA, Goddard Space Flight Center, Code 691, Greenbelt, MD 20771; Gerald M. Zeosky, MA, New York State Police, 1220 Washington Street, Building 30, Albany, NY 12226; Samuel Floyd, MS, and Timothy McClanahan, MS, NASA, Goddard Space Flight Center, Code 691, Greenbelt, MD 20771 The goal of this presentation is to serve as an update on the progress made in establishing a portable X-Ray fluorescence XRF ; unit for the non-destructive characterization of evidence at crime scenes. Much as DNA testing and databases revolutionized how forensic science impacted criminal investigations in the last decade, this presentation will impact the forensic community and or humanity by demonstrating how rapid characterization of crime scene evidence has the potential to do this and more for the next decade. Unintended consequences of enhanced analytical power sensitivity and selectivity ; include increased sophistication of forensic science methods and longer, more complicated analysis. While these analyses ultimately lead to more probative information, the information is not available to the investigator at the scene during the critical first stages of a case. Unlike common television depictions, the results of most forensic analyses often are not available for months, rendering them virtually useless to the investigation. Right after an incident, suspects are "off balance" and have not had sufficient time to evaluate their circumstances. The ability to refute specific claims scientifically would give investigators the necessary leverage during interrogation. Over the past 8 years, significant progress has been made to address this. A unique partnership developed between NASA's Goddard Space Flight Center, forensic scientists, law enforcement personnel, academicians, and prosecuting attorneys to adapt space exploration technology developed by Goddard to problems encountered at the crime scene. The concept of civilians who can benefit from technology developed for space exploration is not a new one. The notion of "dual use" began under President Reagan, and has continued as a key strategic focal area for NASA ever since. As a result of this partnership, a small, portable X-Ray fluorescence XRF ; unit has been developed. XRF as a forensic tool in general, and in alpha and beta tests performed by the team, has been applied in multiple laboratory settings to characterize various forms of trace evidence. Much as DNA testing and databases revolutionized how forensic science impacted criminal investigations in the last decade, rapid characterization of crime scene evidence has the potential to do this and more for the next decade. As the investigative power of DNA testing and DNA database searching is fully realized, significant efforts by others are underway to extend this DNA technology to crime scene applications. A portable XRF unit will serve as one of the tools that will allow investigators to extend this potential enhancement of investigative timeliness to not just biological evidence, but all of the evidence found at crime scenes. This will allow scene personnel to focus investigative efforts on those areas and items at the scene that are most likely to yield probative information needed, and resolve violent crimes as quickly as possible. This lowers recidivism rates both in theory and in every conceivable practical sense. Beta testing of the portable XRF prototype has demonstrated the ability to characterize various forms of physical evidence. Advanced spectral analysis software allows complex spectra to be analyzed quickly. Through the application of special NASA expertise, software such as PENELOPE allows forward Monte Carlo modeling of spectra.
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Ou have had your training in both psychiatry and neurology. Your focus over the past 30 years has been on translating preclinical findings to the clinic. It seems that you have not worked in clinical practice during that period. After my training, also in philosophy next to psychiatry and neurology, I have been active as a neuropsychiatrist for 15 years, with child psychiatry as my main focus. In the 60s 70s Minimal Brain Dysfunction MBD, now called attention-deficit hyperactivity disorder ADHD ; has been proposed as a disease entity but not recognized so in France and elsewhere in Europe. In the U.S.A. there was a neuroscience research performed on the possible involvement of damage in dopamine DA ; cells in the brain as a basis of MBD. I got the opportunity to spend a postdoctoral period in Pasadena Caltech ; , in the laboratory of Jimmy Olds, the discoverer of brain reward systems and self-stimulation. During this period I had the possibility to visit frequently the UCLA Medical Center, only forty minutes from Pasadena, to understand how these colleagues were conducting both research on MBD and clinical practice. It was a very exciting period and Los Angeles was a great place, a sort of paradise, for neuroscience as a new discipline. Back in France, I tried to mix clinical practice and research, but my endeavour was beyond its time, even after a few years it was still not possible. At that time psychoanalysis was deleteriously dominant. I turned definitively to basic neuroscience; there was no other choice for my generation, at least in France. I started a laboratory in Bordeaux with the idea to promote a sort of new discipline, experimental psychopathology. I also returned to California to continue my training in basic neuroscience in a series of summers 14 in fact ; working with George Koob for a lifetime collaboration, in Floyd Bloom's lab, first in the Salk, then in the Scripps Institutes. In Bordeaux I created a CNRS Centre Nationale de la Recherche Scientifique ; , then an INSERM laboratory and also a large Institute for Neuroscience, l'Institut Franois Magendie. Franois Magendie, a MD from Bordeaux, has been professor at le Collge de France and the mentor of Claude Bernard. I have had the good fortune along my scientific career to have been surrounded by fantastic and first class collaborators from various horizons and countries and to have been granted enough funds to do what I wanted to do. Why did you direct your research to addiction, has this been serendipity or a clear choice? How do you look at addiction as compared to 30 years ago? and pregabalin.
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HEALTH PSYCHOLOGY ABC of psychological medicine, edited by Richard Mayou, Michael Sharpe and Alan Carson BRITISH MEDICAL JOURNAL 2003 WM 90 AS SPH Applying psychology to health, by Philip Banyard 1996 WM 90 SPH Cambridge handbook of psychology, health and medicine, edited by Andrew Baum and others 1997 WM 90 AS SPH Changing health behaviour: intervention and research with social cognition models, edited by Derek Rutter and Lyn Quine 2002 WA 300 AS Foundations of health psychology, by Ron Roberts and Tony Towell 2001 WM 90 SPH AS Health psychology, by Anthony J. Curtis 2000 WM 90 AS Health psychology: a textbook, 2nd edn., by Jane Ogden 2000 WM 90 SPH Health psychology: biopsychosocial interactions, 3rd edn., by Edward P. Sarafino 1998 WM 90 SPH Health psychology: an introduction for nurses and other health care professionals, 2nd edn., by Neil Niven 1994 WM 90 SPH AS Health psychology for health care professionals, by Neil Niven 2000 WM 90 AS SPH Health psychology: process and applications, 2nd edn., edited by Annabel Broome and Sue Llewelyn 1995 WM 90 SPH AS The health psychology reader, edited by David F. Marks 2002 WM 90 AS SPH Health psychology: theory, research and practice, by David F. Marks 2000 WM 90 AS Introduction to clinical health psychology, by Paul Bennett 2000 WM 90 AS SPH.
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Systemic" ; , affecting many different tissues. All of the systemic forms have the potential to provide the full range of benefits and risks ; associated with ET. Estrogen injections are not recommended for menopause therapy, since the estrogen level in the blood fluctuates from a high peak after injection to a low level later on, instead of supplying a consistent level. Women with a uterus who use systemic ET should also use another hormone progestogen ; to protect the uterus from endometrial cancer. Local dosage form. The current vaginal estrogen products cream, ring, or tablet ; are considered "local" therapy affecting only a specific or localized area of the body ; . Local dosage forms, sometimes called "vaginal" forms, are used to treat moderate to severe vaginal dryness and atrophy. With a local form, only a very small amount of estrogen circulates through the body. Therefore, these vaginal ET products do not relieve hot flashes or prevent osteoporosis. It is not clear whether all low-dose local ET regimens increase the risk for endometrial cancer. However, with higher doses of local ET, enough estrogen may get into the blood to possibly affect the uterus; thus, adding progestogen is recommended. Custom ET products. In addition to the estrogen products listed see Chart on page 43 ; , custom-made formulations prepared by a compounding pharmacist from a prescription are also available. These products are different from those patented products that are FDAapproved, providing women with different types and amounts of estrogen as well as ways of using it. These include capsules, skin creams and gels, subdermal implants pellets placed under the skin ; , sublingual tablets under the tongue ; , rectal suppositories, and nasal sprays. One type of estrogen only available in custom.
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Cases are won and lost on technicalities, and I've been involved in a few. I've been named in cases 19 years out for which I have no recollection of it in the medical record of what happened when I was a resident, was excused from the case, and you're still held for being involved in litigation. I don't want to belabor the point of the malpractice crisis, because it's real. As being one of the doctors in the trenches, I can tell you it's real and it hurts. Now, what can we do? Everybody suffers in a malpractice case. My family suffers. I suffer. I'm being called a bad doctor. I'm being told that I should be stripped of my privileges. I'm being told that I unfit to work. How do my kids go to college? How do I feed my family? I don't know anything else to do. I a bad business person. I admit it. Now what can we do? Well, I think one of the things that has to be done is I think there needs to be a freeze on premiums to last year's level. I think there have to be caps whether we like them or not. There should be periodic payments. We have to really adjust or think about the statute of limitations. I mean, 21 years out for a delivery that occurred 21 years ago is a bit much for a statute of limitation. We need review committees involving doctors, lawyers, maybe even some laypeople, nurses -- whoever -- to review claims to see if they are meritorious. One of the other things that troubles me the most is that you get in a case, and then the expert witness has never practiced for five, ten, fifteen years, or he's from out of state or, one of the most distressing things, is that they're not of your specialty. They're of another specialty and they're.
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Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles, California Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California Department of Pathology, University of Southern California School of Medicine, Los Angeles, California Grant sponsor: Neil Bogart Memorial Laboratories of the T.J. Martell Foundation for Leukemia, Cancer, and AIDS Research; Grant sponsor: National Cancer Institute; Grant numbers: CA82830 and CA60104. * Correspondence to: C.P. Reynolds, Division of HematologyOncology, MS# 57 Children's Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027. E-mail: preynolds chla c.
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