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Asia Pacific excluding Japan ; We delivered another strong year in Asia Pacific, with sales up 15% to $1, 386 million reported 20% ; . AstraZeneca was ranked fourth and was the fastest growing among the top 10 pharmaceutical companies. Sales in the largest market in the region, Australia, were $504 million, driven by a 36% increase in sales of recently launched products excluding an exchange benefit of 8% ; , which more than offset declining sales of Losec. In China, of the 24 multi-nationals surveyed by the Hong Kong Association of the Pharmaceutical Industry, we are the largest prescription drug company third ranking overall ; and with underlying growth of 33% reported 34% ; , we are one of the fastest growing pharmaceutical companies. On an underlying basis, sales in South Korea were up 23% 38% reported ; to $137 million, driven by a strong performance of our recently launched products. Sales in Taiwan increased by 8% on an underlying basis 14% reported ; , in a market where growth was significantly inhibited by government policies. In South East Asia, we enjoyed average underlying growth of 17% with particular success in Thailand 30% ; . Latin America Sales in the Latin America region increased by 17% on an underlying basis reported 25% ; to $579 million, driven by Brazil, Venezuela and Mexico. Sales in the rest of Latin America were up 20%. Merrem remained our best selling product + 16% ; , while sales of Crestor + 27% ; and Nrxium + 34% ; continued to be very dynamic. In Mexico, the largest market in the region, sales reached $233 million. In Brazil, we achieved underlying growth of 18% and N3xium is the brand leader in a highly fragmented market. Middle East & Africa Underlying sales growth in the Middle East was 10% reported 17% ; , driven by strong sales of Nexium, Symbicort and Atacand and propecia.
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Devaluation of currency Phornchanok Cumperayot. Forecasting devaluations of Thai baht. Bangkok : Chulalongkorn University, 1996. 138 p. T E11394 ; Developing countries Boobpha Anuntawat. Performance audit with special reference to development programs . [S.l. : s.n.], [1995]. 61 p. R E10349 ; Danskin, Edith Shaw. The open university as a route to higher education expansion in developing countries : the case of Ramkhamhaeng University, Thailand. London : Institute of Education, London University, 1981. 291 leaves. T E1187 ; Doeve, Willem L.J. Operational multiregional demography in developing countries : an application to Thailand. Voorburg : Netherlands Interuniversity Demographic Institute, 1984. vii, 63 p. R E2396c.1; E2397c.2; E2398c.3 ; Hoffmann, Lutz. Energy demand patterns. Ottawa : Energy Research Group, 1984. 55 p. R E2046 ; Navaretti, Giorgio Barba. Joint ventures in developing countries : transfer of skills and the role of aid agencies. [S.l.] : Centro Studi Lucad' Agliano, 1989. 313 p. R E12937 c.1; E12938 c.2 ; Nuffield Council on Bioethics. The ethics of research related to healthcare in developing countries. London : Council, 2002. 205 p. R E18120 ; Prapant Svetanant. Management of waste and water pollution in Tokyo Metropolitan area : the model example of NIC's. Tokyo : Institute of Developing Economies, 1996. 82 p. R E16334 ; Shields, Linda. A comparative study of the care of hospitalized children in developed and developing countries. Brisbane : University of Queensland, 1998. 305 p. T E14873 ; Thanet Norabhoompipat. Structure of technology : a model for rural development. Bangkok : Thai Khadi Research Institute Thammasart University, 1980. ii, 136 p. R E417 ; . Comparative study of foreign direct investment in Japan and Thailand. [S.l.] : Doshisha University, 1995. 18 p. R E10341 ; Developing countries--Economic conditions Nongnooch Poramacom. The impacts of resource endowments on agricultural sectors of developing countries. Oklahoma : Oklahoma State University, 1995. 101 p. T E9565 ; Developing countries--Foreign economic relations Jaspersen, Frederick Z. Adjustment experience and growth prospects of the semi-industrial economics. Washington D.C. : World Bank, 1981. 132 p. R E22315 ; Development administration . The role of Namprom irrigation project, Chaiyapoom province, in development administration for agricultural water management. : , 2541. 184 . 99743 ; 25582.
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Merck bettered its first-quarter earnings forecast reporting 78 cents per share ex-restructuring charges. The company eliminated 1, 800 positions during the first quarter as part of its plan to eliminate 7, 000 positions by the end of 2008. Wyeth's first quarter profit increased 4% from the year-ago period. Sales of antidepressant Effexor and gastrointestinal reflux drug Protonix increased 9% and 18%, respectively. The company expects sales of Effexor, Protonix and four other products to exceed $1 billion by year-end. AstraZeneca's first quarter earnings increased 37% as sales of its five key products including heartburn drug Nsxium and antipsychotic drug Seroquel increased 25%. Challenges remain. Branded drugs with sales of about $100 billion are expected to go off-patent during the next five years. Among cholesterol-lowering drugs, Merck's Zocor loses patent protection on June 23. Costconscious insurers already appear to be switching patients from competing medications to Zocor to facilitate a switch to low-cost generics as soon as they become available. Additionally, Teva Pharmaceutical TEVAFPHAX ; has won final approval from the U. S. FDA for its version of Bristol-Myers Squibb's cholesterol drug Pravachol. The introduction of cont'd on page 5.
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| Nexium iv stabilityPhRMA members are concerned that the French System will have long lasting detrimental effects on the growth and development of the pharmaceutical industry in France, and substantially erode the quality of health care in France. Specifically, the French system i ; places limits on and thus lowers the efficiency of production of medicinal products, due to a quota imposed on annual sales, and ii ; discourages research and development into new medicinal products, because limits placed on growth will lower the return on investment needed to engage in such activities. This will lead to a loss of employment, substantial reduction of investment in research and development, delay in the introduction of innovative products on the French market, and ultimately harm the long-term competitiveness of the research-based pharmaceutical industry. Government-Imposed Price and Volume Controls In recent years, the French Government has expanded the coverage and scope of health services provided within the Social Security system. However, it has simultaneously pursued a strict policy of limiting health expenditures; as a result, the health system faces both unfunded mandates and unrealistic expectations regarding spending, particularly in the area of pharmaceuticals. As part of a broader plan to reduce the budget deficit, France has adopted several laws and regulations to control Social Security expenditures on pharmaceuticals. These measures, however, control not only overall drug spending, but also individual company sales, therapeutic class sales, and specific product sales. As a result, the government is controlling growth of the pharmaceutical industry and of individual companies, and by extension, is determining market share. Most importantly, these government-imposed pricing measures have a disproportionate impact on innovative firms. Because researchbased firms with innovative products are primarily non-French, the impact of this system on foreign firms is much greater than the impact on domestic firms. First, the government sets an overall target for the annual increase in health spending; for the year 2000, the approved rate was 2%. If spending exceeds this rate, the.
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With expertise in the development, manufacturing and marketing of injectable pharmaceutical products, primarily used worldwide by hospitals. Sicor's finished dosage products manufacturing operations account for 32% of its total revenue, and is comprised of a portfolio of products that includes oncology, anesthesiology, and critical care. Sicor's 2001 revenues totaled nearly $370 million. According to its website, Sicor operates its business through several subsidiaries. 126. Defendant Gensia Sicor Pharmaceuticals, Inc. "Gensia Sicor" ; , a Delaware.
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Lexchin, 1993; Chren & Landefeld, 1994; Gibbons, et al., 1998; Griffith, 1999; Wazana, 2000 ; . Based on these and other studies, it is difficult to dispute that the reported $11 billion to $12 billion a year spent on marketing to physicians is significantly contributing to the rising cost of pharmaceuticals. In 1999, the drug industry spent more than $6.2 billion to detail products to physicians--nearly $1.6 billion of which was spent on promotional meetings and events Scott-Levin, 2000 ; . According to Kirkpatrick, writing in New York magazine, the typical drug representative is female, about 30 years old, well dressed, attractive, and with bonuses can make over $140, 000 per year Kirkpatrick, 2000 ; . Often drug representative's "weapon of choice" is food--catering lunches, dinners, and medical education events where they hope to have access to physicians to tout their products. Although drug representatives often offer physicians small gifts such as pens, mugs, and stethoscopes, they have been known to pick up the tab for a medical student's textbooks or pay honoraria to physicians of $500 to $1500 to speak at a medical symposium or work as a consultant to a pharmaceutical company Kirkpatrick, 2000 ; . A recent publication by Scott-Levin, Physician Meeting and Event Audit, reports, "The number of pharmaceutical company-sponsored physician meetings and events skyrocketed from 70, 000 in 1993 to 280, 000 in 1999, an increase of 25 percent" Scott-Levin, 2000 ; . Meetings and events continue to be an effective way to get doctors' attention. Physicians attend 49 percent of the events sponsored by drug companies. Forty-five percent of the events were at restaurants and hotel locations, accounting for 18 percent of invitations. At sponsored meal events, allergists and immunologists had the highest acceptance rates--68 percent Scott-Levin, November, 2000, p. 8. ; . Physician marketing has become so successful that pharmaceutical companies are spending millions of dollars to determine the best way to increase and maximize promotions. For instance, an extensive review of the literature has shown that numerous research organizations have expanded their informational capabilities to produce dozens of "how-tomarket" publications for pharmaceutical manufacturers. Taylor Nelson Sofres Intersearch TNSI ; is an example of one such company. TNSI currently produces a report called the Sample Monitor which provides physician-specific information about the use of samples, how they're displayed, how much of a particular drug is in a physician's office inventory, or if a particular physician is oversupplied or undersupplied with a particular drug. In one of their marketing advertisements, TNSI offers to track for pharmaceutical manufacturers 17 physician specialties and 17 therapeutic classes of medications using information obtained by interviewing specific specialty physicians by region and specific locality TNSI, 2000.
The acknowledgement of cognitive abstract thinking ; limitations and its effect on patients is just beginning to be recognized. Almost a third of women with breast cancer who receive chemotherapy after surgery complain of some degree of cognitive impairment. Higher doses of chemotherapy often result in more frequent and severe deficits. Problems may be reported with memory, concentration, word finding deficits, organizational skills, arithmetic problem solving, and reasoning. These deficits may last for a few weeks or years. Fearing that memory problems may be a sign of metastasis to the brain, some people are hesitant to discuss these problems with their physician. Compensatory strategies can improve one's ability to organize information, maintain attention, and recall words and information. In some instances, speech therapy and or medications may be helpful. Again, it is important to tell your health care provider about any cognitive problems you might feel you are experiencing. - 48.
Master when, if, and how to obtain refills of their medication" Gazmararian et al., 2003 ; . The problem will only continue to grow as patients are asked to assume more responsibility for self-care in a complex health care system. Pharmacists, as the most accessible health professionals, are in a unique position to identify patients who struggle with inadequate health literacy and to assist patients in overcoming the barriers that may be limiting their ability to function adequately in the healthcare system Youmans & Schillinger, 2003 ; . Pharmacists currently use several methods to assist low literate patients with learning how to take medications correctly. One strategy is to draw a symbol e.g., a red heart for a heart medication ; on the label of the prescription bottle and the same symbol on paper accompanied by instructions of how to take the medication. Some medication containers have a mechanism that indicates how often a medication should be taken and there are even `talking' prescription bottles that play a message recorded by the pharmacist for an individual patient. Another strategy sometimes used by pharmacists is to scotch tape actual pills to an instruction sheet. This technique is undesirable because many medications are costly and look very similar. It is unreliable because the pills may not remain attached to the instruction sheet rendering the instructions meaningless. Small children may also find and ingest them. Many of the articles that document the prevalence and consequences of low health literacy make only brief references to using pictorial images to communicate health and drug information. There is some evidence that people more easily retain pictorial information than verbal, written information Doak & Doak; Haber & Myers, 1982 ; . Research that has explored the use of visual learning for communicating medication information has often focused on images such as pictograms that communicate a single idea. Pictograms are effective in stimulating recall of information that was previously learned Dowse & Ehlers, 2001 ; . Since people's interpretations of symbolic information can be variable, providing training in the intended meaning for pictograms is advisable Dowse & Ehlers, 2001 ; . Care must also be taken that the pictograms are culturally appropriate Mansoor & Dowse, 2003 ; . Other research has compared patients' comprehension of medical information using pictorial images accompanied by text. For example, Mansoor & Dowse 2003 ; found that a pictogram accompanying a simplified medication leaflet was preferred by patients over the leaflet with text alone and concluded that pictogram use increased comprehension. Concept maps can incorporate meaningful pictograms to diagram a flow or hierarchy of ideas. They also provide written, visual, and spatial information and this combination is more likely to be retrievable from memory than written information alone Robinson, Robinson, & Katayama, 1999 ; . A visual concept map illustrating daily medication instructions could become a portable tool that a patient could carry with them or post on a bulletin board or refrigerator. 3 Study Purpose.
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